Modelling the Pathophysiological Human Brain Function

Specifically, the framework of methods and technology representing the VPH will have to possess three fundamental attributes: • descriptive: the framework should allow observations made in laboratories, in hospitals and in the field, at a variety of locations worldwide, to be collected, catalogued, organized, shared and combined in any suitable way • integrative: the framework should enable experts to analyse these observations collaboratively and to develop systemic hypotheses that involve the knowledge of multiple scientific disciplines • predictive: the framework should make it possible to interconnect predictive models defined at different scales, with different methods, and with different levels of detail, into systemic networks that provide a concretization of those systemic hypotheses; it should also make it possible to verify their validity by comparison with other clinical or laboratory observations.